产品名称
TM4SF5 Rabbit Polyclonal Antibody
蛋白名称
Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9032
Human Swissprot No.
O14894
Human Swissprot Link
https://www.uniprot.org/uniprot/O14894
特异性
This antibody detects endogenous levels of TM4SF5 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Intestine. Overexpressed in pancreatic cancers.
细胞定位
Lysosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Localization to cell membrane increases during conditions of arginine depletion and translocation to lysosome membrane seen upon arginine repletion. .
功能
Acts as a lysosomal membrane arginine sensor . Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations . Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus . CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression .
