产品名称
RYR1 Rabbit Polyclonal Antibody
蛋白名称
Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6261
Human Swissprot No.
P21817
Human Swissprot Link
https://www.uniprot.org/uniprot/P21817
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20190
Mouse Swissprot No.
E9PZQ0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/E9PZQ0/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/F1LMY4/entry
特异性
This antibody detects endogenous levels of RYR1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Skeletal muscle and brain (cerebellum and hippocampus).
细胞定位
Sarcoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum . The number of predicted transmembrane domains varies between orthologs, but the 3D-structures show the presence of six transmembrane regions. Both N-terminus and C-terminus are cytoplasmic. .
功能
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules . Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm . Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).
