产品名称
CRB3 Rabbit Polyclonal Antibody
蛋白名称
Crumbs protein homolog 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=92359
Human Swissprot No.
Q9BUF7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BUF7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=224912
Mouse Swissprot No.
Q8QZT4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8QZT4/entry
特异性
This antibody detects endogenous levels of CRB3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Preferentially expressed in epithelial tissues (PubMed:14718572). Expressed at high levels in lung, kidney, and colon (PubMed:12527193, PubMed:14718572). Expressed at high levels in retina, colon and mammary glands (PubMed:12527193). Moderately expressed in liver, spleen, pancreas and prostate (PubMed:12527193). Moderately to weakly expressed in the placenta (PubMed:14718572, PubMed:12527193). Weakly expressed in skeletal muscle and small intestine (PubMed:14718572).
细胞定位
Apical cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. .
功能
Involved in the establishment of cell polarity in mammalian epithelial cells . Regulates the morphogenesis of tight junctions . Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity).
