产品名称
PP4R1 Rabbit Polyclonal Antibody
蛋白名称
Serine/threonine-protein phosphatase 4 regulatory subunit 1
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q8TF05
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TF05/entry
Mouse Swissprot No.
Q8K2V1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K2V1
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q8VI02
免疫原
Synthesized peptide derived from part region of human protein
特异性
PP4R1 Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
组织表达
Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.
细胞定位
protein phosphatase 4 complex,
功能
function:Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3.,similarity:Contains 14 HEAT repeats.,subunit:Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complex PPP4C-PPP4R1. Interacts with HDAC3.,tissue specificity:Widely expressed with high expression in cultured mesangial cells. Isoform 1 and isoform 2 are expressed in renal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
