产品名称
ATF7IP Rabbit Polyclonal Antibody
蛋白名称
Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55729
Human Swissprot No.
Q6VMQ6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6VMQ6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54343
Mouse Swissprot No.
Q7TT18
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TT18/entry
特异性
This antibody detects endogenous levels of ATF7IP at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level).
功能
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing . Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 . Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) . Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells .
