产品名称
RNF34 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF34 (EC 6.3.2.-) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger protein 34) (RING finger protein RIFF)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80196
Human Swissprot No.
Q969K3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q969K3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80751
Mouse Swissprot No.
Q99KR6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99KR6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=282845
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYH3/entry
特异性
This antibody detects endogenous levels of RNF34 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
细胞定位
Cell membrane ; Peripheral membrane protein . Endomembrane system ; Peripheral membrane protein . Nucleus . Nucleus speckle . Cytoplasm, cytosol .
功能
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis . May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation . Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN . Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells . Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation .
