产品名称
OSTN Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=344901
Human Swissprot No.
P61366
Human Swissprot Link
https://www.uniprot.org/uniprot/P61366
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=239790
Mouse Swissprot No.
P61364
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P61364/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=360730
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P61365/entry
特异性
This antibody detects endogenous levels of OSTN at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Enriched in neocortical regions of the developing cerebral cortex (PubMed:27830782). Not expressed in other compartments of the neocortical wall or in brain regions such as the hippocampus, striatum, mediodorsal nucleus of the thalamus and cerebellum (PubMed:27830782). Also expressed in bone (PubMed:14523025). In developing neonatal rib bone, present at high level in osteoblasts on bone-forming surfaces, in newly incorporated osteocytes and in some late hypertrophic chondrocytes (at protein level) (PubMed:15923362). In adult bone, localizes specifically to osteoblasts and young osteocytes at bone-forming sites (at protein level) (PubMed:15923362).
功能
Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience . Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex . Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).
