产品名称
OBSCN Rabbit Polyclonal Antibody
基因名称
OBSCN KIAA1556 KIAA1639
蛋白名称
Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84033
Human Swissprot No.
Q5VST9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5VST9
Mouse Swissprot No.
A2AAJ9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2AAJ9/entry
特异性
This antibody detects endogenous levels of OBSCN at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
[Isoform 3]: Cytoplasm, myofibril, sarcomere, M line . Cytoplasm, myofibril, sarcomere, Z line . In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk (PubMed:12527750). Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells (PubMed:12527750).; Cytoplasm, myofibril, sarcomere, M line . Cytoplasm, myofibril, sarcomere, Z line . Cell membrane, sarcolemma . Nucleus . Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles. .
功能
Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle . Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity). Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) .
