产品名称
DCD Rabbit Polyclonal Antibody
蛋白名称
Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117159
Human Swissprot No.
P81605
Human Swissprot Link
https://www.uniprot.org/uniprot/P81605
特异性
This antibody detects endogenous levels of DCD at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Specifically and constitutively expressed in eccrine sweat gland cells (at protein level). Secreted into the sweat at a concentration of 1-10 micrograms/ml.
细胞定位
Secreted .; [Survival-promoting peptide]: Secreted .; [DCD-1]: Secreted . Membrane ; Peripheral membrane protein . Membrane ; Single-pass membrane protein . The secreted peptide assembles into homohexameric complexes that can probably associate with pathogen membranes and also insert into these membranes where they behave as channels. .
功能
[DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization . The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes . Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival . Highly effective against E.coli, E.faecalis, S.aureus and C.albicans . Optimal pH and salt concentration resemble the conditions in sweat . Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues . ; [Survival-promoting peptide]: Promotes survival of neurons and displays phosphatase activity . It may bind IgG .
