产品名称
C1orf51 Rabbit Polyclonal Antibody
蛋白名称
Uncharacterized protein C1orf51
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=148523
Human Swissprot No.
Q8N365
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N365
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=229599
Mouse Swissprot No.
Q3TQ03
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TQ03/entry
特异性
This antibody detects endogenous levels of C1orf51 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Nucleus, PML body . Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. .
功能
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
