产品名称
ARAP3 Rabbit Polyclonal Antibody
蛋白名称
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64411
Human Swissprot No.
Q8WWN8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WWN8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=106952
Mouse Swissprot No.
Q8R5G7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R5G7/entry
特异性
This antibody detects endogenous levels of ARAP3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. .
功能
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
