产品名称
TRPM6 Rabbit Polyclonal Antibody
蛋白名称
Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140803
Human Swissprot No.
Q9BX84
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BX84
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=225997
Mouse Swissprot No.
Q8CIR4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CIR4/entry
特异性
This antibody detects endogenous levels of TRPM6 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.
细胞定位
Cell membrane ; Multi-pass membrane protein.
功能
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
