产品名称
AQR Rabbit Polyclonal Antibody
蛋白名称
Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9716
Human Swissprot No.
O60306
Human Swissprot Link
https://www.uniprot.org/uniprot/O60306
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11834
Mouse Swissprot No.
Q8CFQ3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CFQ3/entry
特异性
This antibody detects endogenous levels of AQR at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Nucleus, nucleoplasm . Localizes to speckle-like regions of the nucleoplasm. .
功能
Involved in pre-mRNA splicing as component of the spliceosome . Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis . Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly . May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing . Has ATP-dependent RNA helicase activity and can unwind double-stranded RNA molecules with a 3' overhang (in vitro) .
