产品名称
LAS1L Rabbit Polyclonal Antibody
蛋白名称
Ribosomal biogenesis protein LAS1L (Protein LAS1 homolog)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81887
Human Swissprot No.
Q9Y4W2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y4W2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76130
Mouse Swissprot No.
A2BE28
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2BE28/entry
特异性
This antibody detects endogenous levels of LAS1L at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export. .
功能
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
