产品名称
DDX6 Rabbit Polyclonal Antibody
蛋白名称
Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1656
Human Swissprot No.
P26196
Human Swissprot Link
https://www.uniprot.org/uniprot/P26196
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13209
Mouse Swissprot No.
P54823
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P54823/entry
特异性
This antibody detects endogenous levels of DDX6 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Abundantly expressed in most tissues.
细胞定位
Cytoplasm, P-body . Cytoplasm . Nucleus . Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:28216671). Upon cellular stress, relocalizes to stress granules (PubMed:26184334). .
功能
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions . Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation . In the process of mRNA degradation, plays a role in mRNA decapping . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts .
