产品名称
APC2 Rabbit Polyclonal Antibody
基因名称
ANAPC2 APC2 KIAA1406
蛋白名称
Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29882
Human Swissprot No.
Q9UJX6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UJX6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=99152
Mouse Swissprot No.
Q8BZQ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BZQ7/entry
特异性
This antibody detects endogenous levels of APC2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.
