产品名称
MCM-BP Rabbit Polyclonal Antibody
蛋白名称
Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79892
Human Swissprot No.
Q9BTE3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BTE3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=210711
Mouse Swissprot No.
Q8R3C0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R3C0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=309009
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B1H268/entry
特异性
This antibody detects endogenous levels of MCM-BP at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
功能
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
