产品名称
ACD Rabbit Polyclonal Antibody
基因名称
ACD PIP1 PTOP TINT1 TPP1
蛋白名称
Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65057
Human Swissprot No.
Q96AP0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96AP0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=497652
Mouse Swissprot No.
Q5EE38
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EE38/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=307798
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4FZR5/entry
特异性
This antibody detects endogenous levels of ACD at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Chromosome, telomere .
功能
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
