产品名称
TDRD3 Rabbit Polyclonal Antibody
蛋白名称
Tudor domain-containing protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81550
Human Swissprot No.
Q9H7E2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H7E2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=219249
Mouse Swissprot No.
Q91W18
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91W18/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=306066
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q66HC1/entry
特异性
This antibody detects endogenous levels of TDRD3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules. .
功能
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
