产品名称
SARA Rabbit Polyclonal Antibody
基因名称
ZFYVE9 MADHIP SARA SMADIP
蛋白名称
Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9372
Human Swissprot No.
O95405
Human Swissprot Link
https://www.uniprot.org/uniprot/O95405
特异性
This antibody detects endogenous levels of SARA at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
细胞定位
Cytoplasm. Early endosome membrane.
功能
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
