产品名称
TTI1 Rabbit Polyclonal Antibody
蛋白名称
TELO2-interacting protein 1 homolog (Protein SMG10)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9675
Human Swissprot No.
O43156
Human Swissprot Link
https://www.uniprot.org/uniprot/O43156
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75425
Mouse Swissprot No.
Q91V83
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91V83/entry
特异性
This antibody detects endogenous levels of TTI1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
