产品名称
TP53RK Rabbit Polyclonal Antibody
基因名称
TP53RK C20orf64 PRPK
蛋白名称
TP53-regulating kinase (EC 2.7.11.1) (Nori-2) (p53-related protein kinase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=112858
Human Swissprot No.
Q96S44
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96S44
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76367
Mouse Swissprot No.
Q99PW4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99PW4/entry
特异性
This antibody detects endogenous levels of TP53RK at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in testis. Weakly expressed in heart kidney and spleen.
细胞定位
Cytoplasm . Nucleus .
功能
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine . The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 . TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation .
