产品名称
SCIN Rabbit Polyclonal Antibody
蛋白名称
Adseverin (Scinderin)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85477
Human Swissprot No.
Q9Y6U3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y6U3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20259
Mouse Swissprot No.
Q60604
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60604/entry
特异性
This antibody detects endogenous levels of SCIN at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in megakaryocytes.
细胞定位
Cytoplasm, cytoskeleton . Cell projection, podosome .
功能
Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane . Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles . Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways .
