产品名称
MORC3 Rabbit Polyclonal Antibody
基因名称
MORC3 KIAA0136 ZCWCC3
蛋白名称
MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled-coil domain protein 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23515
Human Swissprot No.
Q14149
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14149
特异性
This antibody detects endogenous levels of MORC3 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney.
细胞定位
Nucleus, nucleoplasm . Nucleus matrix . Nucleus, PML body . Chromosome . Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. .
功能
Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response . Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function . Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity . Binds RNA in vitro . Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 . The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 . ; (Microbial infection) May be required for influenza A transcription during viral infection .
