产品名称
RBM7 Rabbit Polyclonal Antibody
蛋白名称
RNA-binding protein 7 (RNA-binding motif protein 7)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10179
Human Swissprot No.
Q9Y580
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y580
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67010
Mouse Swissprot No.
Q9CQT2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQT2/entry
特异性
This antibody detects endogenous levels of RBM7 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nucleoplasm . Nucleus . Excluded from the nucleolus. .
功能
RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation . NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs . Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs) . Participates in several biological processes including DNA damage response (DDR) and stress response . During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome . Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability .
