产品名称
LRRC8D Rabbit Polyclonal Antibody
基因名称
LRRC8D LRRC5 UNQ213/PRO239
蛋白名称
Leucine-rich repeat-containing protein 8D (Leucine-rich repeat-containing protein 5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55144
Human Swissprot No.
Q7L1W4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7L1W4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=231549
Mouse Swissprot No.
Q8BGR2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BGR2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=305131
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U308/entry
特异性
This antibody detects endogenous levels of LRRC8D at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). .
功能
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine . Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress . LRRC8A and LRRC8D are required for the uptake of the drug cisplatin . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol . Mediates the import of the antibiotic blasticidin-S into the cell .
