产品名称
PACSIN1 Rabbit Polyclonal Antibody
蛋白名称
Protein kinase C and casein kinase substrate in neurons protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29993
Human Swissprot No.
Q9BY11
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BY11
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23969
Mouse Swissprot No.
Q61644
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61644/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29704
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z0W5/entry
特异性
This antibody detects endogenous levels of PACSIN1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in brain and, at much lower levels, in heart and pancreas.
细胞定位
Cytoplasm . Cell projection . Cell junction, synapse, synaptosome . Cell projection, ruffle membrane . Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane ; Peripheral membrane protein . Cell junction, synapse . Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. .
功能
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
