产品名称
Teneurin 1 Rabbit Polyclonal Antibody
蛋白名称
Teneurin-1 (Ten-1) (Protein Odd Oz/ten-m homolog 1) (Tenascin-M1) (Ten-m1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10178
Human Swissprot No.
Q9UKZ4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UKZ4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23963
Mouse Swissprot No.
Q9WTS4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTS4/entry
特异性
This antibody detects endogenous levels of Teneurin 1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in fetal brain.
细胞定位
Cell membrane ; Single-pass membrane protein .; [Ten-1 intracellular domain]: Nucleus . Nucleus speckle . Nucleus matrix . Cytoplasm, cytoskeleton .; [Teneurin C-terminal-associated peptide]: Nucleus . Cytoplasm . Cell membrane . Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity). .
功能
Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). ; [Teneurin C-terminal-associated peptide]: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity). ; [Ten-1 intracellular domain]: Induces gene transcription activation.
