产品名称
SURF4 Rabbit Polyclonal Antibody
蛋白名称
Surfeit locus protein 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6836
Human Swissprot No.
O15260
Human Swissprot Link
https://www.uniprot.org/uniprot/O15260
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20932
Mouse Swissprot No.
Q64310
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64310/entry
特异性
This antibody detects endogenous levels of SURF4 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cycles between the endoplasmic reticulum and the Golgi. .
功能
Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion . Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis . Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins . Promotes the secretion of PCSK9 . Also mediates the efficient secretion of erythropoietin (EPO) . May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi .
