产品名称
SEP11 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9NVA2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NVA2/entry
Mouse Swissprot No.
Q8C1B7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C1B7
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941B3GNI6
免疫原
Synthesized peptide derived from human protein . at AA range: 200-280
特异性
SEP11 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009],
组织表达
Widely expressed, except in leukocytes.
细胞定位
Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon . Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
功能
disease:A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with MLL/HRX.,function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subunit:May assemble into a multicomponent structure. Interacts with SEPT12.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
