产品名称
RNF128 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase RNF128 (EC 6.3.2.-) (Gene related to anergy in lymphocytes protein) (RING finger protein 128)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79589
Human Swissprot No.
Q8TEB7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8TEB7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66889
Mouse Swissprot No.
Q9D304
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D304/entry
特异性
This antibody detects endogenous levels of RNF128 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endomembrane system ; Single-pass membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). .
功能
E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
