产品名称
INSC Rabbit Polyclonal Antibody
蛋白名称
Protein inscuteable homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=387755
Human Swissprot No.
Q1MX18
Human Swissprot Link
https://www.uniprot.org/uniprot/Q1MX18
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=233752
Mouse Swissprot No.
Q3HNM7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3HNM7/entry
特异性
This antibody detects endogenous levels of INSC at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.
细胞定位
Cytoplasm . Cytoplasm, cell cortex . Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. .
功能
May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex . Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).
