产品名称
SCAR5 Rabbit Polyclonal Antibody
基因名称
SCARA5 UNQ2938/PRO28700
蛋白名称
Scavenger receptor class A member 5 (Scavenger receptor hlg)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q6ZMJ2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZMJ2/entry
Mouse Swissprot No.
Q8K299
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K299
免疫原
Synthesized peptide derived from human protein . at AA range: 230-310
特异性
SCAR5 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).,similarity:Belongs to the SCARA5 family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 SRCR domain.,subunit:Homotrimer.,
组织表达
Adipose tissue,Muscle,
细胞定位
Cell membrane ; Single-pass type II membrane protein .
功能
function:Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).,similarity:Belongs to the SCARA5 family.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 SRCR domain.,subunit:Homotrimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
