产品名称
C13orf18 Rabbit Polyclonal Antibody
蛋白名称
Uncharacterized protein KIAA0226-like
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80183
Human Swissprot No.
Q9H714
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H714
Mouse Swissprot No.
Q3TD16
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TD16/entry
特异性
This antibody detects endogenous levels of C13orf18 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed weakly in cervical carcinoma cell lines.
细胞定位
Cytoplasmic vesicle, autophagosome membrane ; Peripheral membrane protein . Associates with late autophagic structure (PubMed:28306502). Recruitment to autophagosome membrane is promoted by autophagic stimuli (PubMed:28306502). .
功能
Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy . Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex . Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes . Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) . In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable).
