产品名称
SPP Rabbit Polyclonal Antibody
基因名称
HM13 H13 IMP1 PSL3 SPP MSTP086
蛋白名称
Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81502
Human Swissprot No.
Q8TCT9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8TCT9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14950
Mouse Swissprot No.
Q9D8V0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D8V0/entry
特异性
This antibody detects endogenous levels of SPP at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein ; Lumenal side .; [Isoform 4]: Cell membrane ; Multi-pass membrane protein .
功能
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides . May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein . Involved in the intramembrane cleavage of the integral membrane protein PSEN1 . Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner . May play a role in graft rejection (By similarity).
