产品名称
FTCD Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10841
Human Swissprot No.
O95954
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95954/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14317
Mouse Swissprot No.
Q91XD4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91XD4
Rat Gene Link
https://www.uniprot.org/uniprot/89833
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88618
免疫原
Synthesized peptide derived from human FTCD AA range: 157-207
特异性
This antibody detects endogenous levels of FTCD at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009],
细胞定位
Cytoplasm, cytosol . Golgi apparatus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . More abundantly located around the mother centriole. .
功能
catalytic activity:5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.,catalytic activity:5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH(3).,catalytic activity:5-formyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formyl-L-glutamate.,cofactor:Pyridoxal phosphate.,disease:Defects in FTCD are the cause of glutamate formiminotransferase deficiency [MIM:229100]; also known as formiminoglutamicaciduria (FIGLU-uria). It is an autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.,function:Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.,pathway:Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.,pathway:One-carbon metabolism; tetrahydrofolate pathway.,similarity:In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.,similarity:In the N-terminal section; belongs to the formiminotransferase family.,subunit:Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
