产品名称
EML1 Rabbit Polyclonal Antibody
基因名称
EML1 EMAP1 EMAPL EMAPL1
蛋白名称
Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2009
Human Swissprot No.
O00423
Human Swissprot Link
https://www.uniprot.org/uniprot/O00423
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68519
Mouse Swissprot No.
Q05BC3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q05BC3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362783
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4V8C3/entry
特异性
This antibody detects endogenous levels of EML1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous; expressed in most tissues with the exception of thymus and peripheral blood lymphocytes.
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton . Detected in cytoplasmic punctae. Co-localizes with microtubules (PubMed:24859200, PubMed:25740311). Enriched in perinuclear regions during interphase and in the region of spindle microtubules during metaphase. Enriched at the midzone during telophase and cytokinesis. Detected at growth cones in neurons (By similarity). .
功能
Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
