产品名称
DNAJC9 Rabbit Polyclonal Antibody
蛋白名称
DnaJ homolog subfamily C member 9 (DnaJ protein SB73)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23234
Human Swissprot No.
Q8WXX5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WXX5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=108671
Mouse Swissprot No.
Q91WN1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91WN1/entry
特异性
This antibody detects endogenous levels of DNAJC9 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.
细胞定位
Nucleus . Cytoplasm . Cell membrane . Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock. .
功能
Acts as a dual histone chaperone and heat shock co-chaperone . As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes . May also act as a histone co-chaperone together with TONSL . May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers . Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8 . As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity . Exhibits activity to assemble histones onto DNA in vitro .
