产品名称
NQO2 Rabbit Polyclonal Antibody
蛋白名称
Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.99.2) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P16083
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P16083/entry
Mouse Swissprot No.
Q9JI75
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JI75
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q6AY80
免疫原
Synthesized peptide derived from human protein . at AA range: 40-120
特异性
NQO2 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],
功能
catalytic activity:1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.,cofactor:Binds 1 zinc ion per subunit.,cofactor:FAD.,enzyme regulation:Inhibited by melatonin, resveratrol and 5-hydroxytryptamine.,function:The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.,miscellaneous:Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor.,similarity:Belongs to the NAD(P)H dehydrogenase (quinone) family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
