产品名称
RTEL1 Rabbit Polyclonal Antibody
基因名称
RTEL1 C20orf41 KIAA1088 NHL
蛋白名称
Regulator of telomere elongation helicase 1 (EC 3.6.4.12) (Novel helicase-like)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51750
Human Swissprot No.
Q9NZ71
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NZ71
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=269400
Mouse Swissprot No.
Q0VGM9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q0VGM9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362288
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5RJZ1/entry
特异性
This antibody detects endogenous levels of RTEL1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Colocalizes with PCNA within the replication foci in S-phase cells. .
功能
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
