产品名称
RRBP1 Rabbit Polyclonal Antibody
蛋白名称
Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q9P2E9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P2E9/entry
Mouse Swissprot No.
Q99PL5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99PL5
免疫原
Synthesized peptide derived from human protein . at AA range: 1120-1200
特异性
RRBP1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012],
组织表达
Brain,Epithelium,Pancreas,Uterus,
细胞定位
Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
功能
alternative products:Additional isoforms seem to exist. Additional isoforms are probable deriving from alternative splicing in the repeat region,function:Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
