产品名称
Nir2 Rabbit Polyclonal Antibody
基因名称
PITPNM1 DRES9 NIR2 PITPNM
蛋白名称
Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9600
Human Swissprot No.
O00562
Human Swissprot Link
https://www.uniprot.org/uniprot/O00562
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18739
Mouse Swissprot No.
O35954
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35954/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361694
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2N3/entry
特异性
This antibody detects endogenous levels of Nir2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm. Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Lipid droplet . Cleavage furrow . Midbody . Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835). .
功能
Catalyzes the transfer of phosphatidylinositol (PI) between membranes . Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC . Regulates RHOA activity, and plays a role in cytoskeleton remodeling . Necessary for normal completion of cytokinesis . Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus . Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus . Required for protein export from the endoplasmic reticulum and the Golgi . Binds calcium ions .
