产品名称
EXD2 Rabbit Polyclonal Antibody
基因名称
EXD2 C14orf114 EXDL2
蛋白名称
Exonuclease 3'-5' domain-containing protein 2 (Exonuclease 3'-5' domain-like-containing protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55218
Human Swissprot No.
Q9NVH0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NVH0
Mouse Swissprot No.
Q8VEG4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VEG4/entry
特异性
This antibody detects endogenous levels of EXD2 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Mitochondrion outer membrane ; Single-pass membrane protein . Mitochondrion matrix . Nucleus . Chromosome . Mainly localizes to the mitochondrial outer membrane (PubMed:29599527, PubMed:31127291). May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidences (PubMed:26807646). Recruited to replication forks following replication stress (PubMed:31255466). .
功能
Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor . In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) . Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation . Also involved in the response to DNA damage . Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination . Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks . Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation .
