产品名称
VPS26A Rabbit Polyclonal Antibody
蛋白名称
Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9559
Human Swissprot No.
O75436
Human Swissprot Link
https://www.uniprot.org/uniprot/O75436
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30930
Mouse Swissprot No.
P40336
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P40336/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361846
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AY86/entry
特异性
This antibody detects endogenous levels of VPS26A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Endosome membrane ; Peripheral membrane protein . Early endosome . Localizes to tubular profiles adjacent to endosomes (PubMed:15078903). Predominantly found in early not late endosomes (By similarity). .
功能
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R . Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) . Required for the endosomal localization of WASHC2A (indicative for the WASH complex) . Required for the endosomal localization of TBC1D5 . Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP . Involved in retromer-independent lysosomal sorting of F2R . Involved in recycling of ADRB2 . Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity).
