产品名称
Neurochondrin Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23154
Human Swissprot No.
Q9UBB6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UBB6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26562
Mouse Swissprot No.
Q9Z0E0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z0E0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89791
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35095/entry
特异性
This antibody detects endogenous levels of Neurochondrin at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Abundantly expressed in whole adult brain and in all individual brain regions examined, including spinal cord. Weakly expressed in ovary, testis, fetal brain and small intestine.
细胞定位
Cytoplasm, cytosol . Endosome membrane ; Lipid-anchor . Cell projection, dendrite . Cell junction, synapse, postsynapse . Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation. .
功能
Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling . Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).
