产品名称
GRP Rabbit Polyclonal Antibody
蛋白名称
Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10)]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2922
Human Swissprot No.
P07492
Human Swissprot Link
https://www.uniprot.org/uniprot/P07492
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=225642
Mouse Swissprot No.
Q8R1I2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R1I2/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P24393/entry
特异性
This antibody detects endogenous levels of GRP at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Secreted . Cytoplasmic vesicle, secretory vesicle lumen . Cell projection, neuron projection . In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. .
功能
Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (By similarity). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). ; [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation.
