产品名称
PUS1 Rabbit Polyclonal Antibody
蛋白名称
tRNA pseudouridine synthase A, mitochondrial (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80324
Human Swissprot No.
Q9Y606
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y606
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56361
Mouse Swissprot No.
Q9WU56
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WU56/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304567
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4KM92/entry
特异性
This antibody detects endogenous levels of PUS1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed (PubMed:15108122). High levels of expression found in brain and skeletal muscle (PubMed:15108122).
细胞定位
[Isoform 1]: Mitochondrion .; [Isoform 2]: Nucleus . Cytoplasm .
功能
Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs . Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA . Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' . Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions . Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing . Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA .
