产品名称
SPAG4 Rabbit Polyclonal Antibody
蛋白名称
Sperm-associated antigen 4 protein (Outer dense fiber-associated protein SPAG4) (SUN domain-containing protein 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6676
Human Swissprot No.
Q9NPE6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NPE6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245865
Mouse Swissprot No.
Q9JJF2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJF2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83623
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O55034/entry
特异性
This antibody detects endogenous levels of SPAG4 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Predominantly epressed in testis. Expressed in ejaculated spermatozoa (at protein level).
细胞定位
Membrane ; Multi-pass membrane protein . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, flagellum axoneme . Nucleus envelope . Nucleus inner membrane . In spermatids, it is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Colocalized with SEPT12 at the nuclear periphery in round spermatids, at sperm neck in elongated spermatids and at midpiece regions in ejaculated spermatozoa (PubMed:25775403). .
功能
Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.
