产品名称
PLEKHF1 Rabbit Polyclonal Antibody
基因名称
PLEKHF1 APPD LAPF ZFYVE15
蛋白名称
Pleckstrin homology domain-containing family F member 1 (PH domain-containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (PH and FYVE domain-containing protein 1) (Phafin-1) (Zinc finger FYVE domain-containing protein 15)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79156
Human Swissprot No.
Q96S99
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96S99
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72287
Mouse Swissprot No.
Q3TB82
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TB82/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=308543
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q68FU1/entry
特异性
This antibody detects endogenous levels of PLEKHF1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.
细胞定位
Nucleus . Cytoplasm, perinuclear region . Lysosome . Translocates to lysosome during apoptosis.
功能
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
