产品名称
THG1L Rabbit Polyclonal Antibody
蛋白名称
Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54974
Human Swissprot No.
Q9NWX6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9NWX6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66628
Mouse Swissprot No.
Q9CY52
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CY52/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=303067
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5M965/entry
特异性
This antibody detects endogenous levels of THG1L at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in many tissues.
细胞定位
Cytoplasm . Mitochondrion outer membrane .
功能
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion . By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress .
